Are cephalosporins safe for use in penicillin allergy without prior allergy evaluation?. The economic burden of antibiotic treatment of penicillin-allergic patients in internal medicine wards of a general tertiary care hospital. Management of patients with a history of allergy to beta-lactam antibiotics. 2016 6(8): a025247.īlumenthal KG, Peter JG, Trubiano JA, Phillips EJ. Cold Spring Harbor perspectives in medicine. Β-lactams and β-lactamase inhibitors: An overview. Evaluation and management of penicillin allergy: A review. Shenoy ES, Macy E, Rowe T, Blumenthal KG. Presumed β-lactam allergy and cross-reactivity in the operating theater: A practical approach. Hermanides J, Lemkes BA, Prins JM, Hollmann MW, Terreehorst I. Herein is presented a review of the immunologic mechanisms implicated in penicillin and cephalosporin cross-reactivity and a practical approach to the use of cephalosporins in patients allergic to penicillin. A number of studies indicate that the R1 side chain, rather than the ring itself, is the determining factor for cross-reactivity. Penicillins and cephalosporins share a common beta-lactam ring and side chains. The potential cross-reactivity between penicillin and cephalosporin has very significant therapeutic implications. The incorrect diagnosis prevents patients from receiving a highly effective therapy.
Immunoallergology and Pediatric Pulmonology Unit, Department of Pediatrics, Unidade II, Centro Hospitalar Vila Nova de Gaia/EspinhoĬephalosporin, cross-reactivity, penicillin, side chain AbstractĪllergic reactions to beta-lactam antibiotics are the most common cause of allergic drug reactions. Department of Allergy and Clinical Immunology, Unidade I, Centro Hospitalar Vila Nova Gaia/ Espinho
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